Results
| PMID | 27337799 |
| Gene Name | TNF |
| Condition | Endometriosis (ovarian) |
| Association |
Associated |
| Population size | 122 |
| Population details | 122 (64 patients with ovarian endometriosis, 58 infertility cases caused by male side were used as control group) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IL-6, TNFA |
| Other associated phenotypes |
Female infertility |
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Zhonghua Yi Xue Za Zhi. 2015 Dec 15;95(47):3829-32. Ning, Yanchun| Liu, Baolian| Han, Baosheng| Guo, Jian| Liu, Xiurong| Fan, Guiling| Guo, Chang| Wang, Fenglan| Zhou, Jin| Yin, Lirong OBJECTIVE: To observe the effect of follicular fluid IL-6, TNF-alpha on the clinical outcome of in vitro fertilization and embryo transfer (IVF-ET) in patients with ovarian endometriosis. METHOD: From June 2013 to June 2014, the data of 64 (from Tangshan Maternal and Child Health Hospital IVF center) ovarian endometriosis patients was analyzed retrospectively. 58 infertility cases caused by male side were used as control group. Oocyte retrieval rate, M II oocytes rate, fertilization rate, recovery-intracytoplasmic sperm injection (R-ICSI) rate, good quality embryo rate, biochemical pregnancy rate and clinical pregnancy rate were analyzed and compared between two groups. Changes in the expression of follicular fluid IL-6, TNF-alpha were detected. RESULTS: Oocyte retrieval rate, M II oocytes rate, fertilization rate, good quality embryo rate, biochemical pregnancy rate and clinical pregnancy rate in ovarian endometriosis group were significantly lower than those in the control group (all P < 0.05), while R-ICSI rate increased in ovarian endometriosis group compared with control group (P < 0.05). IL-6, TNF-alpha expressions of follicular fluid were higher in affected side of ovarian endometriosis patients than those in the unaffected side and those in control group. CONCLUSION: Inflammation microenvironment of the follicular fluid may influence IVF-ET outcomes in ovarian endometriosis patients. Mesh Terms: Case-Control Studies| Embryo Transfer| Endometriosis/*pathology| Female| *Fertilization in Vitro| Follicular Fluid/*chemistry| Humans| Infertility, Female/*pathology| Inflammation/*pathology| Interleukin-6/chemistry| Pregnancy| Pregnancy Rate| |
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